• Allergy treatment
  • H1-receptor antagonists
• Antimicrobials for systemic use
• Antiparasitic drugs
• Cardiovascular system
• Dermatology
• Drugs affecting metabolism
• Drugs used in sensory organ disorders
• Gastrointestinal tract
• Haemopoietic system and blood
• Locomotor system
• Nervous system
• Respiratory system
• Systemic hormones
• Urogenital system and Sexual hormones

Allergy treatment

H1-receptor antagonists

1. H1-receptor antagonists overview
2. I generation antihistamines
3. II generation antihistamines
4. III generation antihistamines

The most widely used anti-allergic drugs are antagonists of allergy mediators, which are called antihistamines, or H1-receptor antagonists. The main mechanism of anti-allergic effect of this drug class is the ability to competitively block H1-receptors without affecting H2-and H3-receptors. The biological effects of histamine are very diverse and depend on the point of application of the mediator: from the part of the respiratory system it may be bronchospasm, swelling of the mucous membrane of the nasal cavity, hypersecretion; skin - itching, hyperemia, and many more.

There are 6 main groups of chemical substances that are used for systemic inhibition of H1-receptors, according to WHO classification:

1. aminoalkyl ethers - diphenhydramine, clemastine, etc.
2. substituted alkylamines dimethindene, chlorphenamine, etc.
3. substituted ethylenediamines - chloropyramine, methapyrilene, mepyramine, etc.
4. piperazin derivatives cetirizine, parachloramine, etc.
5. phenothiazine derivatives promethazine, alimemazine, etc.
6. others, including cyproheptadine, astemizole, fexofenadine, loratadine, desloratadine etc.

Another classification which is based on the therapeutic effects expressed by the drugs includes 3 following groups:

Please select category Allergy treatment Antimicrobials for systemic use Antiparasitic drugs Cardiovascular system Dermatology Drugs affecting metabolism Drugs used in sensory organ disorders Gastrointestinal tract Haemopoietic system and blood Locomotor system Nervous system Other preparations Respiratory system Systemic hormones Urogenital system and Sexual hormones Please select subcategory Please select ingredient Please select pharmform Please select pathology

Age:

Weight: kg

Step 1 (of 3)

• Fosfocreatine
• Levocetirizine
• Metoprolol
• Telavancin
• Triamcinolone acetonide, Tetracycline
• Ouabain
• Betahistine
• Nicergoline
• Olmesartan
• Methyldopa, Hydrochlorothiazide